CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men

Toshiyuki Morii, Yoichi Ohno, Norihiro Kato, Hiroshi Hirose, Hiroshi Kawabe, Keiichi Hirao, Takashi Eguchi, Tatsuya Maruyama, Matsuhiko Hayashi, Ikuo Saito, Yoshio Yazaki, Takao Saruta

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Macrophages uptake oxidized low-density lipoprotein (LDL) via a scavenger receptor such as CD36 from plasma, and then become foam cells. We examined the association of CD36 gene single nucleotide polymorphisms (SNPs) with certain metabolic characteristics in a young male Japanese population (n494). The G allele in a SNP located at 30215 on the 3'-untranslated region (UTR) was significantly orrelated with the plasma LDL-cholesterol concentrations (r=0.13, p<0.01). The difference in LDL-cholesterol concentrations was 10mg dl -1 between GG- and AA-genotype carriers (p<0.05). The CD36 gene SNP is a novel maker of the variation in the LDL-cholesterol levels in young Japanese men.

本文言語English
ページ(範囲)207-212
ページ数6
ジャーナルBiomarkers
14
4
DOI
出版ステータスPublished - 2009 6 1

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

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