CD7 positive acute lymphoblastic leukemia successfully treated with high dose cytosine arabinoside and mitoxantrone: A case report

Hideaki Nakajima, Masahiro Kizaki, Yohko Kawai, Akaru Ishida, Michihide Tokuhira, Kiyoaki Watanabe, Yasuo Ikeda

研究成果: Article査読

2 被引用数 (Scopus)

抄録

A 45-year-old woman with acute lymphoblastic leukemia (ALL) who failed to achieve complete remission (CR) after one course of induction chemotherapy with vincristine, daunorubicin, prednisolone and l-asparaginase was successfully treated with a high dose of cytosine arabinoside (Ara-C) and mitoxantrone. The leukemic blasts were CD7, 19, 33, and 38 antigens positive, and had a rearrangement in the T-cell receptor δ chain gene. The karyotype was normal. Primary induction failure and positivity for myeloid antigens are both reported to be poor prognostic factors for ALL. Nevertheless, this patient was successfully treated with the high dose Ara-C and mitoxantrone, and she remains in CR for over 20 months. Combination chemotherapy with high dose Ara-C and mitoxantron may be of benefit for refractory ALL with both CD7 and myeloid antigens.

本文言語English
ページ(範囲)114-117
ページ数4
ジャーナルKeio Journal of Medicine
45
2
DOI
出版ステータスPublished - 1996 6

ASJC Scopus subject areas

  • 医学(全般)

フィンガープリント

「CD7 positive acute lymphoblastic leukemia successfully treated with high dose cytosine arabinoside and mitoxantrone: A case report」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル