Cdk5 phosphorylation of ErbB4 is required for tangential migration of cortical interneurons

Sonja Rakić, Shigeaki Kanatani, David Hunt, Clare Faux, Anna Cariboni, Francesca Chiara, Shabana Khan, Olivia Wansbury, Beatrice Howard, Kazunori Nakajima, Margareta Nikolić, John G. Parnavelas

研究成果: Article

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Interneuron dysfunction in humans is often associated with neurological and psychiatric disorders, such as epilepsy, schizophrenia, and autism. Some of these disorders are believed to emerge during brain formation, at the time of interneuron specification, migration, and synapse formation. Here, using a mouse model and a host of histological and molecular biological techniques, we report that the signaling molecule cyclin-dependent kinase 5 (Cdk5), and its activator p35, control the tangential migration of interneurons toward and within the cerebral cortex by modulating the critical neurodevelopmental signaling pathway, ErbB4/phosphatidylinositol 3-kinase, that has been repeatedly linked to schizophrenia. This finding identifies Cdk5 as a crucial signaling factor in cortical interneuron development in mammals.

元の言語English
ページ(範囲)991-1003
ページ数13
ジャーナルCerebral Cortex
25
発行部数4
DOI
出版物ステータスPublished - 2015 4 1

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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    Rakić, S., Kanatani, S., Hunt, D., Faux, C., Cariboni, A., Chiara, F., Khan, S., Wansbury, O., Howard, B., Nakajima, K., Nikolić, M., & Parnavelas, J. G. (2015). Cdk5 phosphorylation of ErbB4 is required for tangential migration of cortical interneurons. Cerebral Cortex, 25(4), 991-1003. https://doi.org/10.1093/cercor/bht290