cDNA cloning and chromosomal localization of the human ciliary neurotrophic factor gene

Hidehiro Yokoji, Takeshi Ariyama, Ryosuke Takahashi, Johji Inazawa, Hidemi Misawa, Takeo Deguchi

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Full-length cDNA for human ciliary neurotrophic factor (CNTF) was isolated from a human sciatic nerve cDNA library. Sequence analysis revealed that the longest cDNA was comprised of a 48-bp 5′-untranslated region, a 600-bp coding region and a 1207-bp 3′-untranslated region containing four ATTA pentamer motifs and a polyadenylation sequence. The transcription starting point was assigned at 81 bp upstream of the initiation methionine by 5′ RACE analysis. Using the cDNA and genomic DNA fragment including the entire intron region as mixed probes, the human CNTF gene was localized to the long arm of chromosome 11 at region q12 by fluorescence in situ hybridization.

本文言語English
ページ(範囲)175-178
ページ数4
ジャーナルNeuroscience Letters
185
3
DOI
出版ステータスPublished - 1995 2 13
外部発表はい

ASJC Scopus subject areas

  • Neuroscience(all)

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