Cell-encapsulating chitosan-collagen hybrid hydrogel conduit for peripheral nerve regeneration

Shun Itai, Karin Suzuki, Yuta Kurashina, Hiroo Kimura, Tsuyoshi Amemiya, Kazuki Sato, Masaya Nakamura, Hiroaki Onoe

研究成果: Conference contribution

抄録

This paper presents a tube-shaped chitosan-collagen hydrogel conduit containing cells for peripheral nerve regeneration. The conduit is simply made by molding, and composed of two layers: A chitosan layer strengthens the conduit mechanically, and a collagen layer provides a scaffold for cells supporting the axonal extension. By using our conduit, peripheral nerves could be regenerated in high quality, because those encapsulated cells release paracrine factors including nerve growth factors (NGF) and supply good environments for nerve tissue reconstruction. We examined the biocompatibility and bioabsorbability of our conduit, and the results represent that our device induced the extension of neurites of neural model cells and was dissolved away in specific terms. We believe this conduit will become a cutting-edge conduit for peripheral nerve surgeries.

本文言語English
ホスト出版物のタイトル23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
出版社Chemical and Biological Microsystems Society
ページ880-881
ページ数2
ISBN(電子版)9781733419000
出版ステータスPublished - 2019
イベント23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
継続期間: 2019 10 272019 10 31

出版物シリーズ

名前23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
CountrySwitzerland
CityBasel
Period19/10/2719/10/31

ASJC Scopus subject areas

  • Bioengineering
  • Chemical Engineering (miscellaneous)

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