Cell fibers: Construction of centimeter-scale 3D tissues by weaving

Hiroaki Onoe, Riho Gojo, Yukiko Tsuda, Daisuke Kiriya, Midori Kato-Negishi, Shoji Takeuchi

研究成果: Conference contribution

9 被引用数 (Scopus)

抄録

This paper describes "cell fibers" for engineering centimeter-scale 3D heterogeneous artificial tissues. Cells (both cell lines and primary cells) proliferate in our collagen/alginate core-shell hydrogel fibers, and completely fill the core space to form cell fibers. We found that the cell fibers keep their fibrous shapes even after removing the shell alginate hydrogel, and that they still maintain their bioactivities. As a demonstration, we constructed (i) tissue fabric sheets by weaving the cell fibers and (ii) 3D heterogeneous coil-like tissue tubes by reeling up two different cell fibers. These cell fibers would be an extremely effective tool as building elements for constructing large-scale functional tissues.

本文言語English
ホスト出版物のタイトル14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
ページ629-631
ページ数3
出版ステータスPublished - 2010 12 1
外部発表はい
イベント14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
継続期間: 2010 10 32010 10 7

出版物シリーズ

名前14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
1

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
国/地域Netherlands
CityGroningen
Period10/10/310/10/7

ASJC Scopus subject areas

  • 制御およびシステム工学

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