Cell output, cell cycle duration and neuronal specification: A model of integrated mechanisms of the neocortical proliferative process

V. S. Caviness, T. Goto, T. Tarui, T. Takahashi, P. G. Bhide, R. S. Nowakowski

研究成果: Article

154 被引用数 (Scopus)

抄録

The neurons of the neocortex are generated over a 6 day neuronogenetic interval that comprises 11 cell cycles. During these 11 cell cycles, the length of cell cycle increases and the proportion of cells that exits (Q) versus re-enters (P) the cell cycle changes systematically. At the same time, the fate of the neurons produced at each of the 11 cell cycles appears to be specified at least in terms of their laminar destination. As a first step towards determining the causal interrelationships of the proliferative process with the process of laminar specification, we present a two-pronged approach. This consists of (i) a mathematical model that integrates the output of the proliferative process with the laminar fate of the output and predicts the effects of induced changes in Q and P during the neuronogenetic interval on the developing and mature cortex and (ii) an experimental system that allows the manipulation of Q and P in vivo. Here we show that the predictions of the model and the results of the experiments agree. The results indicate that events affecting the output of the proliferative population affect both the number of neurons produced and their specification with regard to their laminar fate.

本文言語English
ページ(範囲)592-598
ページ数7
ジャーナルCerebral Cortex
13
6
DOI
出版ステータスPublished - 2003 6 1

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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