Cell signaling: IP3 receptor types 2 and 3 mediates exocrine secretion underlying energy metabolism

Akira Futatsugi, Takeshi Nakamura, Maki K. Yamada, Etsuko Ebisui, Kyoko Nakamura, Kelko Uchida, Tetsuya Kitaguchi, Hiromi Takashi-Iwanaga, Tetsuo Noda, Jun Aruga, Katsuhiko Mikoshiba

研究成果: Article査読

231 被引用数 (Scopus)

抄録

Type 2 and type 3 inositol 1,4,5-trisphosphate receptors (IP3R2 and IP3RB) are intracellular calcium-release channels whose physiological roles are unknown. We show exocrine dysfunction in IP 3R2 and IP3R3 double knock-out mice, which caused difficulties in nutrient digestion. Severely impaired calcium signaling in acinar cells of the salivary glands and the pancreas in the double mutants ascribed the secretion deficits to a lack of intracellular calcium release. Despite a normal caloric intake, the double mutants were hypoglycemic and lean. These results reveal IP3R2 and IP3R3 as key molecules in exocrine physiology underlying energy metabolism and animal growth.

本文言語English
ページ(範囲)2232-2234
ページ数3
ジャーナルScience
309
5744
DOI
出版ステータスPublished - 2005 9 30
外部発表はい

ASJC Scopus subject areas

  • General

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