Cell surface N-glycans-mediated isolation of mouse neural stem cells

Makoto Hamanoue, Hideyuki Okano

研究成果: Review article査読

3 被引用数 (Scopus)

抄録

The isolation of neural stem cells (NSCs) has been hampered by the lack of valid cell-surface antigens on NSCs, and novel valuable markers have been proposed. Glycan (oligosaccharide chain) is a potential candidate as a marker to isolate NSCs, because the species and the combination order of saccharides in glycan generate remarkable structural diversity and specificity. At present, the expression of hundreds of glycoconjugates with glycans have been found in the NSCs; however, just a few glycan-epitopes have been identified as valuable cell-surface markers. This review focused on the isolation of NSC using glycoprotein, especially complex type N-glycans. The cell-surface N-glycan-mediated isolation of NSCs is therefore expected to provide a comprehensive understanding of the biologic characteristics of NSCs in the brain, and thereby help to develop novel strategies in the field of regenerative medicine.

本文言語English
ページ(範囲)1433-1438
ページ数6
ジャーナルJournal of Cellular Physiology
226
6
DOI
出版ステータスPublished - 2011 6月

ASJC Scopus subject areas

  • 生理学
  • 臨床生化学
  • 細胞生物学

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