Cell transplantation for spinal cord injury focusing on iPSCs

Masaya Nakamura, Osahiko Tsuji, Satoshi Nori, Yoshiaki Toyama, Hideyuki Okano

研究成果: Review article査読

13 被引用数 (Scopus)

抄録

Introduction: Reports of functional recovery from spinal cord injury (SCI) after the transplantation of neural stem cells (NSCs) derived from fetus/embryonic stem cells (ESCs), has raised great expectations for the successful clinical use of stem cell transplantation therapy. However, the ethical issues involved in destroying human embryos or fertilized oocytes to obtain NSCs have been a major obstacle to developing clinically useful stem cell sources, and the transplantation of stem cells isolated from other human embryonic tissues has not yet been developed for use in clinical applications. Areas covered: Recently, induced pluripotent stem cells (iPSCs), which can serve as a source of cells for autologous transplantation, have been attracting a great deal of attention as a clinically viable alternative to stem cells obtained directly from tissues. In this review, the authors outline the neural induction of ESC/iPSC, their therapeutic efficacy in SCI and their safety in vivo. Expert opinion: Although iPSCs offer great promise as the cell source for autologous transplantation for SCI, safety issues including tumorigenicity should be determined prior to the clinical trial.

本文言語English
ページ(範囲)811-821
ページ数11
ジャーナルExpert Opinion on Biological Therapy
12
7
DOI
出版ステータスPublished - 2012 7月

ASJC Scopus subject areas

  • 薬理学
  • 創薬
  • 臨床生化学

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