Cellular assemblages by using polymer chains possessing bio-affinities for tissue engineering

Makiko Kawada, Keiji Fujimoto

研究成果: Paper査読

抄録

Human umbilical vein endothelial cells were modified with polymer chains to display cell-adhesive sites through the ligand-receptor interaction on the cell surface. We prepared a poly (ethylene oxide) (PEO) having a cell-adhesive peptide Gly-Arg-Gly-Asp-Ser (GRGDS) at both ends to link among cells. The polymer chains were added to the HUVEC suspension to obtain cell agglomerates. SEM observations revealed that cells closely attached to form agglomerates. Cell agglomerates could adhere onto the collagen-coated PS plate and spread from their circumference. Eventually, cell shapes changed from agglomerates to a monolayer. We found that cell growth was facilitated when cells remained agglomerated and that the size and the morphologies of cell agglomerates significantly influenced on the cell proliferation.

本文言語English
ページ数1
出版ステータスPublished - 2006 10 19
イベント55th SPSJ Annual Meeting - Nagoya, Japan
継続期間: 2006 5 242006 5 26

Other

Other55th SPSJ Annual Meeting
CountryJapan
CityNagoya
Period06/5/2406/5/26

ASJC Scopus subject areas

  • Engineering(all)

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