Central action of atrial natriuretic polypeptide on blood pressure in conscious rats

Hiroshi Itoh, Kazuwa Nakao, Narito Morii, Takayuki Yamada, Shozo Shiono, Makoto Sakamoto, Akira Sugawara, Yoshihiko Saito, Goro Katsuura, Teruo Shiomu, Masami Eigyo, Akira Matsushita, Hiroo Imura

研究成果: Article査読

65 被引用数 (Scopus)

抄録

The effect of intracerebroventricular administration of atrial natriuretic polypeptide on blood pressure was studied in conscious, unrestrained rats. The intracer-ebroventricular injection of α-human atrial natriuretic polypeptide did not promote any significant change in basal blood pressure, whereas it attenuated central angiotensin II-induced pressor response in a dose-dependent manner. The plasma atrial natriuretic polypeptide level did not change after the central administration of α-human atrial natriuretic polypeptide. These data implicate atrial natriuretic polypeptide as a factor in blood pressure regulation in the central nervous system.

本文言語English
ページ(範囲)745-749
ページ数5
ジャーナルBrain Research Bulletin
16
5
DOI
出版ステータスPublished - 1986 5
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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