抄録
The first hybrid mice ('shiverer*mld' mice) produced by intercrossing the homozygotes of the shiverer (BALB/c strain) and mld (MDB/Dt strain) were used for investigating the fine structure of the myelin lamellae, immunoreactive pattern for myelin basic proteins (MBP) and Golgi impregnated images of oligodendrocytes, with special reference to the influence of aging. All of the hybrid mice had an intermediate coat color between the white of the shiverer and black-brown of the mld, and revealed the same neurological symptoms, intention tremor, ataxic behavior, etc., as those of the shiverer and mld. The central myelin lamellae of the 'shiverer*mld' mouse exhibited the similar characteristics to the shiverer type rather than the mld type from the standpoint of the infrequent occurrence of major dense lines, although they did display a tendency to increase major dense lines with aging like the mld. Observation of the immunohistochemical preparations for MBP showed that immunopositive myelin sheaths were present in the white matter, although they were far more infrequent than those of the mld mutant, probably reflecting the amount of major dense lines. Thus, in the CNS of the 'shiverer*mld' mouse, the MBP-synthesis was possibly much more disturbed than in the mld mutant, or at least, revealed an intermediate pattern between the mld and shiverer.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 271-280 |
| ページ数 | 10 |
| ジャーナル | Brain Research |
| 巻 | 449 |
| 発行部数 | 1-2 |
| DOI | |
| 出版物ステータス | Published - 1988 5 24 |
| 外部発表 | Yes |
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ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
これを引用
Central myelin in the first hybrid mice produced by intercrossing homozygotes of shiverer and myelin-deficient mutants. / Inoue, Yoshiro; Takahashi, Shiro; Takayama, Chitoshi; Inoue, Kaoru; Okano, Hideyuki; Mikoshiba, Katsuhiko.
：: Brain Research, 巻 449, 番号 1-2, 24.05.1988, p. 271-280.研究成果: Article
}
TY - JOUR
T1 - Central myelin in the first hybrid mice produced by intercrossing homozygotes of shiverer and myelin-deficient mutants
AU - Inoue, Yoshiro
AU - Takahashi, Shiro
AU - Takayama, Chitoshi
AU - Inoue, Kaoru
AU - Okano, Hideyuki
AU - Mikoshiba, Katsuhiko
PY - 1988/5/24
Y1 - 1988/5/24
N2 - The first hybrid mice ('shiverer*mld' mice) produced by intercrossing the homozygotes of the shiverer (BALB/c strain) and mld (MDB/Dt strain) were used for investigating the fine structure of the myelin lamellae, immunoreactive pattern for myelin basic proteins (MBP) and Golgi impregnated images of oligodendrocytes, with special reference to the influence of aging. All of the hybrid mice had an intermediate coat color between the white of the shiverer and black-brown of the mld, and revealed the same neurological symptoms, intention tremor, ataxic behavior, etc., as those of the shiverer and mld. The central myelin lamellae of the 'shiverer*mld' mouse exhibited the similar characteristics to the shiverer type rather than the mld type from the standpoint of the infrequent occurrence of major dense lines, although they did display a tendency to increase major dense lines with aging like the mld. Observation of the immunohistochemical preparations for MBP showed that immunopositive myelin sheaths were present in the white matter, although they were far more infrequent than those of the mld mutant, probably reflecting the amount of major dense lines. Thus, in the CNS of the 'shiverer*mld' mouse, the MBP-synthesis was possibly much more disturbed than in the mld mutant, or at least, revealed an intermediate pattern between the mld and shiverer.
AB - The first hybrid mice ('shiverer*mld' mice) produced by intercrossing the homozygotes of the shiverer (BALB/c strain) and mld (MDB/Dt strain) were used for investigating the fine structure of the myelin lamellae, immunoreactive pattern for myelin basic proteins (MBP) and Golgi impregnated images of oligodendrocytes, with special reference to the influence of aging. All of the hybrid mice had an intermediate coat color between the white of the shiverer and black-brown of the mld, and revealed the same neurological symptoms, intention tremor, ataxic behavior, etc., as those of the shiverer and mld. The central myelin lamellae of the 'shiverer*mld' mouse exhibited the similar characteristics to the shiverer type rather than the mld type from the standpoint of the infrequent occurrence of major dense lines, although they did display a tendency to increase major dense lines with aging like the mld. Observation of the immunohistochemical preparations for MBP showed that immunopositive myelin sheaths were present in the white matter, although they were far more infrequent than those of the mld mutant, probably reflecting the amount of major dense lines. Thus, in the CNS of the 'shiverer*mld' mouse, the MBP-synthesis was possibly much more disturbed than in the mld mutant, or at least, revealed an intermediate pattern between the mld and shiverer.
KW - Double mutation
KW - Morphology
KW - Myelin
KW - Myelin deficient (mld)
KW - Shiverer
UR - http://www.scopus.com/inward/record.url?scp=0023913625&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023913625&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(88)91043-8
DO - 10.1016/0006-8993(88)91043-8
M3 - Article
C2 - 3395848
AN - SCOPUS:0023913625
VL - 449
SP - 271
EP - 280
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -