Centrosome amplification in adult T-cell leukemia and human T-cell leukemia virus type 1 Tax-induced human T cells

Takayuki Nitta, Masayuki Kanai, Eiji Sugihara, Masakazu Tanaka, Binilian Sun, Toshiro Nagasawa, Shunro Sonoda, Hideyuki Saya, Masanao Miwa

研究成果: Article査読

34 被引用数 (Scopus)

抄録

Centrosomes play pivotal roles in cell polarity, regulation of the cell cycle and chromosomal segregation. Centrosome amplification was recently described as a possible cause of aneuploidy in certain solid tumors and leukemias. ATL is a T-cell malignancy caused by HTLV-1. Although the precise mechanism of cell transformation is unclear, the HTLV-1-encoded protein, Tax, is thought to play a crucial role in leukemogenesis. Here we demonstrate that lymphocytes isolated from patients with ATL show centrosome amplification and that a human T cell line shows centrosome amplification after induction of Tax, which was suppressed by CDK inhibitors. Micronuclei formation was also observed after centrosome amplification in Tax-induced human T cells. These findings suggest that Tax deregulates CDK activity and induces centrosome amplification, which might be associated with cellular transformation by HTLV-1 and chromosomal instability in HTLV-1-infected human T cells.

本文言語English
ページ(範囲)836-841
ページ数6
ジャーナルCancer science
97
9
DOI
出版ステータスPublished - 2006 9
外部発表はい

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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