Changes in Anterior Pituitary Function during ACTH Therapy for Patients with Infantile Spasms

Akira Shimizu, Tohru Seki, Kenji Ohyama, Takao Takahashi, Yuichi Takuma, Katsuaki Hirai, Masao Aihara, Kazuo Hatakeyama

研究成果: Article査読

抄録

Serum cortisol, prolactin (PRL), TSH, GH, LH and FSH levels were measured before and immediately after daily ACTH-Z therapy (0.01 mg/kg/day, 1∼2 weeks) for 5 patients with infantile spasms and one patient with myoclonus epilepsy. Total number of ACTH-Z therapy were 8 times, and all patients became seizure free after ACTH-Z therapy. In 6 occasions, TRH, LH-RH and insuline tolerance tests were performed before and after daily ACTH-Z therapy. Serum cortisol levels were significantly increased after daily ACTH-Z therapy but all other hormone levels were significantly decreased. In TRH and LH-RH tolerance tests, peak levels and increments of PRL, LH and FSH were significantly decreased after daily ACTH-Z therapy and those of TSH were mildly decreased. In one case insulin tolerance test revealed an adequate decrease of blood glucose before and after ACTH-Z therapy, and there was a poor GH response after ACTH-Z therapy. Daily ACTH-Z therapy was thought to suppress secretion of anterior pituitary hormones.

本文言語English
ページ(範囲)445-452
ページ数8
ジャーナルNO TO HATTATSU
21
5
DOI
出版ステータスPublished - 1989
外部発表はい

ASJC Scopus subject areas

  • 小児科学、周産期医学および子どもの健康
  • 臨床神経学

フィンガープリント

「Changes in Anterior Pituitary Function during ACTH Therapy for Patients with Infantile Spasms」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル