TY - JOUR
T1 - Changes in high mannose-type glycoproteins of peripheral blood mononuclear cells in cirrhosis patients
AU - Miyaguchi, Shingo
AU - Morizane, Toshio
AU - Kagawa, Tatehiro
AU - Guevara, Ferdinand Morales
AU - Saito, Hidetsugu
AU - Tsuchiya, Masaharu
PY - 1995/1
Y1 - 1995/1
N2 - Glycoproteins of peripheral blood mononuclear cells (PBMC) in patients with liver cirrhosis (LC) have not yet been studied. In the present study, we investigated high mannose-type glycoproteins of PBMC from patients with LC. We showed that [2-3H]mannose uptake by PBMC and binding of glycoproteins from PBMC to concanavalin A (Con A)-Sepharose were significantly lower in patients with LC than in healthy subjects. These results indicate that high mannose-type glycoproteins of PBMC are decreased in patients with LC. High mannose-type glycoproteins play an important role in the formation of functional high-affinity interleukin-2 (IL-2) receptors. Thus, the decrease of high mannose-type glycoproteins may be one of the factors affecting the function of T or natural killer (NK) cells, which require IL-2 receptors to exert various immunological functions, in patients with LC.
AB - Glycoproteins of peripheral blood mononuclear cells (PBMC) in patients with liver cirrhosis (LC) have not yet been studied. In the present study, we investigated high mannose-type glycoproteins of PBMC from patients with LC. We showed that [2-3H]mannose uptake by PBMC and binding of glycoproteins from PBMC to concanavalin A (Con A)-Sepharose were significantly lower in patients with LC than in healthy subjects. These results indicate that high mannose-type glycoproteins of PBMC are decreased in patients with LC. High mannose-type glycoproteins play an important role in the formation of functional high-affinity interleukin-2 (IL-2) receptors. Thus, the decrease of high mannose-type glycoproteins may be one of the factors affecting the function of T or natural killer (NK) cells, which require IL-2 receptors to exert various immunological functions, in patients with LC.
KW - High mannose-type glycoprotein
KW - Liver cirrhosis
KW - Peripheral mononuclear cells
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U2 - 10.1016/0928-4346(94)00155-X
DO - 10.1016/0928-4346(94)00155-X
M3 - Article
AN - SCOPUS:0028874224
SN - 1386-6346
VL - 3
SP - 41
EP - 47
JO - Hepatology Research
JF - Hepatology Research
IS - 1
ER -