CHAPTER 7: CE-MS for Anionic and Cationic Metabolic Profiling: System Optimization and Applications

Akiyoshi Hirayama, Tomoyoshi Soga

研究成果: Chapter

1 被引用数 (Scopus)

抄録

Capillary electrophoresis-mass spectrometry (CE-MS) has proven to be an important technology for metabolomics studies. Most primary metabolite intermediates contain hydroxyl, amino, carboxyl and phosphate groups and, therefore, are charged, which makes them suitable for CE-MS analysis. The major advantages of CE-MS are its high resolution and the fact that almost any charged metabolite (both cationic and anionic) can be analyzed by only two analytical modes. CE-MS can be readily applied to various kinds of biological samples. This chapter highlights the general CE-MS conditions specifically developed for profiling cationic and anionic metabolites, and also focuses on several biological samples frequently used in medical and biochemical metabolomics, including blood (serum and plasma), urine, tissue, cultured cells and other related samples.

本文言語English
ホスト出版物のタイトルNew Developments in NMR
編集者Rawi Ramautar
出版社Royal Society of Chemistry
ページ134-160
ページ数27
6
ISBN(電子版)9781782624479, 9781782628545, 9781849736435, 9781849739139
ISBN(印刷版)9781788010863, 9781788011044
DOI
出版ステータスPublished - 2018

出版物シリーズ

名前New Developments in NMR
番号6
2018-January
ISSN(印刷版)2044-253X
ISSN(電子版)2044-2548

ASJC Scopus subject areas

  • 分析化学
  • 放射線学、核医学およびイメージング
  • 分光学

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