CHAPTER 7: CE-MS for Anionic and Cationic Metabolic Profiling: System Optimization and Applications

Akiyoshi Hirayama, Tomoyoshi Soga

研究成果: Chapter

1 引用 (Scopus)

抄録

Capillary electrophoresis-mass spectrometry (CE-MS) has proven to be an important technology for metabolomics studies. Most primary metabolite intermediates contain hydroxyl, amino, carboxyl and phosphate groups and, therefore, are charged, which makes them suitable for CE-MS analysis. The major advantages of CE-MS are its high resolution and the fact that almost any charged metabolite (both cationic and anionic) can be analyzed by only two analytical modes. CE-MS can be readily applied to various kinds of biological samples. This chapter highlights the general CE-MS conditions specifically developed for profiling cationic and anionic metabolites, and also focuses on several biological samples frequently used in medical and biochemical metabolomics, including blood (serum and plasma), urine, tissue, cultured cells and other related samples.

元の言語English
ホスト出版物のタイトルNew Developments in NMR
出版者Royal Society of Chemistry
ページ134-160
ページ数27
エディション6
DOI
出版物ステータスPublished - 2018 1 1

出版物シリーズ

名前New Developments in NMR
番号6
2018-January
ISSN(印刷物)2044-253X
ISSN(電子版)2044-2548

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Capillary electrophoresis
Capillary Electrophoresis
Mass spectrometry
Mass Spectrometry
Metabolites
Metabolomics
Hydroxyl Radical
Cultured Cells
Blood
Phosphates
Cells
Urine
Tissue
Technology
Plasmas
Serum

ASJC Scopus subject areas

  • Analytical Chemistry
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy

これを引用

Hirayama, A., & Soga, T. (2018). CHAPTER 7: CE-MS for Anionic and Cationic Metabolic Profiling: System Optimization and Applications. : New Developments in NMR (6 版, pp. 134-160). (New Developments in NMR; 巻数 2018-January, 番号 6). Royal Society of Chemistry. https://doi.org/10.1039/9781788012737-00134

CHAPTER 7 : CE-MS for Anionic and Cationic Metabolic Profiling: System Optimization and Applications. / Hirayama, Akiyoshi; Soga, Tomoyoshi.

New Developments in NMR. 6. 編 Royal Society of Chemistry, 2018. p. 134-160 (New Developments in NMR; 巻 2018-January, 番号 6).

研究成果: Chapter

Hirayama, A & Soga, T 2018, CHAPTER 7: CE-MS for Anionic and Cationic Metabolic Profiling: System Optimization and Applications. : New Developments in NMR. 6 Edn, New Developments in NMR, 番号 6, 巻. 2018-January, Royal Society of Chemistry, pp. 134-160. https://doi.org/10.1039/9781788012737-00134
Hirayama A, Soga T. CHAPTER 7: CE-MS for Anionic and Cationic Metabolic Profiling: System Optimization and Applications. : New Developments in NMR. 6 版 Royal Society of Chemistry. 2018. p. 134-160. (New Developments in NMR; 6). https://doi.org/10.1039/9781788012737-00134
Hirayama, Akiyoshi ; Soga, Tomoyoshi. / CHAPTER 7 : CE-MS for Anionic and Cationic Metabolic Profiling: System Optimization and Applications. New Developments in NMR. 6. 版 Royal Society of Chemistry, 2018. pp. 134-160 (New Developments in NMR; 6).
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