Characteristics of glioma stem cells

Oltea Sampetrean, Hideyuki Saya

研究成果: Article査読

41 被引用数 (Scopus)

抄録

The cancer stem cell theory postulates that tumors are sustained by a select cell population with specific features, such as self-renewal ability and the capacity to give rise to a heterogeneous mass of tumor cells. The existence of such cells has been demonstrated for glioblastoma, with these cells being referred to as glioma stem cells (GSCs). Glioblastomas are notoriously heterogeneous tumors, however, and the isolation and characterization of their stem cells will require further investigations. Furthermore, the lack of unequivocal markers for GSCs and a partial overlap in characteristics with other cells often lead to confusion. Here, we review the characteristics necessary for a glioma cell to be considered a stem cell, and we adopt our murine glioblastoma model based on genetically modified neural stem cells to illustrate and discuss the GSC concept.

本文言語English
ページ(範囲)209-214
ページ数6
ジャーナルBrain tumor pathology
30
4
DOI
出版ステータスPublished - 2013 10月

ASJC Scopus subject areas

  • 腫瘍学
  • 臨床神経学
  • 癌研究

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