Characteristics of leiomyosarcoma: Induction of hematogenous metastasis by isolated uterine mesenchymal tumor stem-like cells

Takuma Hayashi, Kenji Sano, Tomoyuki Ichimura, Yae Kanai, Dorit Zharhary, Hiroyuki Aburatani, Nobuo Yaegashi, Ikuo Konishi

研究成果: Article

抜粋

Background/Aim: Uterine leiomyosarcoma (Ut- LMS) is a refractory tumor that repeatedly recurs with hematogenous metastasis, which may be due to the presence of drug-resistant tumor stem cells. Its treatment is limited to surgical procedures. We previously reported that Ut-LMS spontaneously developed in mice deficient in the proteasome component low-molecular mass polypeptide 2 (LMP2). We showed that LMP2 expression was significantly attenuated specifically in human Ut-LMS. The aim of this study was to investigate the role of LMP2 in hematogenous metastasis using xenograft models with tumor stem-like cells. Materials and Methods: We isolated tumor stem-like cells from LMP2- negative primary human Ut-LMS cells established from a human Ut-LMS tissue using the side population (SP) procedure. These cells were used to develop xenograft models with tumor stem-like cells. Results: Human Ut-LMS stem-like cells showed stronger hematogenous metastatic potential than normal Ut-LMS cells. Tumor stem-like cells also had the potential to differentiate into vascular endothelial cells through VEGF-A signaling. Conclusion: These results reflect frequent hematogenous metastasis by human Ut-LMS in clinical settings, and may lead to the development of treatments that inhibit hematogenous metastasis in Ut-LMS.

元の言語English
ページ(範囲)1255-1265
ページ数11
ジャーナルAnticancer research
40
発行部数3
DOI
出版物ステータスPublished - 2020 1 1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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