Characterization and cell transfection of pDNA/chitosan nanoparticles coated with hyaluronic acid

Zhi Hong Yang, Yoshiyuki Koyama, Toshinori Sato

研究成果: Paper査読

抄録

In this study, we investigated receptor-mediated transfection of the ternary nanoparticles in which a pDNA/chitosan particles is coated with hyaluronic acid (HA), that is known to specifically bind CD44. It was found that the coating of the pDNA/chiorsan complexes with HA depressed self-aggregation in BSA solution, and its cytotoxicity was very low. Although the ternary nanoparticles was negative charge, the gene expression of luciferase gene on CHO cells which express CD44 were improved, which is well agreed with the cell uptake efficiency.

本文言語English
ページ数1
出版ステータスPublished - 2006 10 19
イベント55th SPSJ Annual Meeting - Nagoya, Japan
継続期間: 2006 5 242006 5 26

Other

Other55th SPSJ Annual Meeting
国/地域Japan
CityNagoya
Period06/5/2406/5/26

ASJC Scopus subject areas

  • 工学(全般)

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