Characterization of a Novel Acidic Polysaccharide with Immunological Activities from the Rhizome of Cnidium officinale

Naoko Ohara, Noriko Shimizu, Ryoko Gonda, Masashi Tomoda

研究成果: Article査読

2 被引用数 (Scopus)

抄録

An acidic polysaccharide, called cnidirhan SIIB, was isolated from the rhizome of Cnidium officinale Makino. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 7.9 x 104. It was composed of L-arabinose, D-galactose and D-galacturonic acid in the molar ratio of 9:11:3, in addition to a few 0-acetyl groups. Reduction of carboxyl groups, methylation analysis, nuclear magnetic resonance and controlled Smith degradation studies indicated that its structural features are composed primarily of α-L-arabino-β-3,6- and 3,4-branched D-galactan type units. The polysaccharide showed very pronounced reticuloendothelial system-potentiating activity in a carbon clearance test and marked anti-complementary activity.

本文言語English
ページ(範囲)1886-1889
ページ数4
ジャーナルChemical and Pharmaceutical Bulletin
42
9
DOI
出版ステータスPublished - 1994

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

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