Characterization of an Acidic Polysaccharide with Immunological Activities from the Tuber of Pinellia ternata

Ryoko Gonda, Masashi Tomoda, Noriko Shimizu, Naoko ōHARA, Hiroko Takagi, Shinobu Hoshino

研究成果: Article査読

9 被引用数 (Scopus)

抄録

An acidic polysaccharide, called pinellian PA, was isolated from the tuber of Pinellia ternata Breit. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 11.8 x 104. Pinellian PA is composed of L-arabinose: n-galactose: L-rhamnose: D-galacturonic acid: D-glucuronic acid in the molar ratio of 5:15:1:3:3, in addition to small amounts of O-acetyl groups and peptide moieties. Reduction of carboxyl groups, methylation analysis and nuclear magnetic resonance studies show that the core structural features include a backbone chain composed of β-1,3-linked D-galactose units. Some of the galactose units in the backbone carry β-1,6-linked D-galactosyl side-chains at position 6. Pinellian PA produces significant potentiation of the reticuloendothelial system, as shown by a carbon clearance test, and also exhibits potent anti-complementary activity.

本文言語English
ページ(範囲)1549-1553
ページ数5
ジャーナルBiological and Pharmaceutical Bulletin
17
12
DOI
出版ステータスPublished - 1994 1月 1

ASJC Scopus subject areas

  • 薬理学
  • 薬科学

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