抄録
SELEX is a conventional method to obtain high affinity nucleic acids to target molecules. In this study, high affinity RNA molecules against SRP19 protein were selected by using a randomized library. The primary and predicted secondary structures of the aptamers are different from those of S-domain RNA which is the natural target of SRP19 protein. Comparison of structural features between S-domain RNA and aptamers might enhance our understanding on RNA-protein interaction.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 265-266 |
| ページ数 | 2 |
| ジャーナル | Nucleic acids symposium series (2004) |
| 発行部数 | 53 |
| 出版物ステータス | Published - 2009 |
| 外部発表 | Yes |
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ASJC Scopus subject areas
- Medicine(all)
これを引用
Characterization of RNA aptamers against SRP19 protein having sequences different from SRP RNA. / Haraguchi, Yuki; Kuwasako, Kanako; Muto, Yutaka; Bessho, Yoshitaka; Nishimoto, Madoka; Yokoyama, Shigeyuki; Kanai, Akio; Kawai, Gota; Sakamoto, Taiichi.
：: Nucleic acids symposium series (2004), 番号 53, 2009, p. 265-266.研究成果: Article
}
TY - JOUR
T1 - Characterization of RNA aptamers against SRP19 protein having sequences different from SRP RNA.
AU - Haraguchi, Yuki
AU - Kuwasako, Kanako
AU - Muto, Yutaka
AU - Bessho, Yoshitaka
AU - Nishimoto, Madoka
AU - Yokoyama, Shigeyuki
AU - Kanai, Akio
AU - Kawai, Gota
AU - Sakamoto, Taiichi
PY - 2009
Y1 - 2009
N2 - SELEX is a conventional method to obtain high affinity nucleic acids to target molecules. In this study, high affinity RNA molecules against SRP19 protein were selected by using a randomized library. The primary and predicted secondary structures of the aptamers are different from those of S-domain RNA which is the natural target of SRP19 protein. Comparison of structural features between S-domain RNA and aptamers might enhance our understanding on RNA-protein interaction.
AB - SELEX is a conventional method to obtain high affinity nucleic acids to target molecules. In this study, high affinity RNA molecules against SRP19 protein were selected by using a randomized library. The primary and predicted secondary structures of the aptamers are different from those of S-domain RNA which is the natural target of SRP19 protein. Comparison of structural features between S-domain RNA and aptamers might enhance our understanding on RNA-protein interaction.
UR - http://www.scopus.com/inward/record.url?scp=77952506567&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952506567&partnerID=8YFLogxK
M3 - Article
C2 - 19749362
AN - SCOPUS:77952506567
SP - 265
EP - 266
JO - Nucleic acids symposium series (2004)
JF - Nucleic acids symposium series (2004)
SN - 1746-8272
IS - 53
ER -