Characterization of the Su Antigen, a Macromolecular Complex of 100/102 and 200-kDa Proteins Recognized by Autoantibodies in Systemic Rheumatic Diseases

Minoru Satoh, Jenifer J. Langdon, Chih Hao Chou, Daniel P. McCauliffe, Edward L. Treadwell, Takashi Ogasawara, Michito Hirakata, Akira Suwa, Philip L. Cohen, Robert A. Eisenberg, Westley H. Reeves

研究成果: Article査読

34 被引用数 (Scopus)

抄録

The Su autoantigen was characterized biochemically using human and murine autoimmune sera and the clinical significance of anti-Su antibodies was studied in 236 Japanese and 160 American patients with systemic rheumatic diseases. Anti-Su in immunodiffusion (ID) was strongly associated with immunoprecipitation of one or more 100- to 102-kDa proteins by MRL/lpr mouse sera (27/32 of ID positive vs 4/20 of ID negative, P = 0.000016), and all four human anti-Su reference sera immunoprecipitated the 100/102-kDa protein(s). In addition, all sera immunoprecipitated a less efficiently labeled ∼200-kDa protein that comigrated on sucrose density gradients with the 100/102-kDa proteins. Based on these data, a complex of the 100/102-kDa and 200-kDa proteins is likely to be the main target of anti-Su antibodies. Three of four anti-Su monospecific sera were negative for immunofluorescent antinuclear antibodies (ANA), suggesting anti-Su antibodies may be associated with a negative ANA in some cases. Autoantibodies to Su were detected frequently by immunoprecipitation in systemic lupus erythematosus (17-21%), scleroderma (13-20%), and overlap syndrome (22-40%) and were associated with autoantibodies to Ku.

本文言語English
ページ(範囲)132-141
ページ数10
ジャーナルClinical Immunology and Immunopathology
73
1
DOI
出版ステータスPublished - 1994 10
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 病理学および法医学
  • 免疫学

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