Characterization of two Polysaccharides Having Activity on the Reticuloendothelial System from the Root of Glycyrrhiza uralensis

Masashi Tomoda, Noriko Shimizu, Mieko Kanari, Ryōko Gonda, Sumiko Arai, Yūko Okuda

研究成果: Article査読

47 被引用数 (Scopus)

抄録

Two polysaccharides, called glycyrrhizans UA and UB, were isolated from the root of Glycyrrhiza uralensis Fischer. They were homogeneous on electrophoresis and gel chromatography, and showed reticuloendothelial system-potentiating activity in a carbon clearance test. Glycyrrhizan UA is composed of L-arabinose: D-galactose: L-rhamnose: D-galacturonic acid in the molar ratio of 20:14:1:3, and glycyrrhizan UB is composed of L-arabinose: D-galactose: D-glucose: L-rhamnose: D-galacturonic acid in the molar ratio of 12:10:1:10:20, in addition to small amounts of O-acetyl groups and peptide moiety, respectively. About 10% (glycyrrhizan UA) and 35% (glycyrrhizan UB) of the D-galacturonic acid residues exist as the methyl esters. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies indicated their structural features.

本文言語English
ページ(範囲)1667-1671
ページ数5
ジャーナルChemical and Pharmaceutical Bulletin
38
6
DOI
出版ステータスPublished - 1990

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

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