Chemical confirmation of the structure of a mutagenic aminophenylnorharman, 9-(4'-aminophenyl)-9H-pyrido[3,4-b]indole: An authentic synthesis of 9-(4'nitrophenyl)-9H- pyrido[3,4-b]indole as its relay compound

Yasuoki Murakami; Nobuyuki Imai; Tsuyoshi Miura; Takashi Sugimura; Keiji Wakabayashi; Yukari Totsuka; Noriyasu Hada; Yuusaku Yokoyama; Hideharu Suzuki; Katsuyoshi Mitsunaga

doi:10.3987/COM-09-S(S)45

Chemical confirmation of the structure of a mutagenic aminophenylnorharman, 9-(4'-aminophenyl)-9H-pyrido[3,4-b]indole: An authentic synthesis of 9-(4'nitrophenyl)-9H- pyrido[3,4-b]indole as its relay compound

Yasuoki Murakami, Nobuyuki Imai, Tsuyoshi Miura, Takashi Sugimura, Keiji Wakabayashi, Yukari Totsuka, Noriyasu Hada, Yuusaku Yokoyama, Hideharu Suzuki, Katsuyoshi Mitsunaga

薬学科

研究成果: Article › 査読

2 被引用数 (Scopus)

抄録

9-(4'-Aminophenyl)-9H-pyrido[3,4-b]indole 2 is a mutagenic compound produced by non-mutagenic norharman 1 and aniline in the presence of S9 mix. 9-(4'-Nitrophenyl)-9H-pyrido[3,4-b]indole 4, the relay compound for synthesis of 2, was synthesized starting from ethyl indole-2-aldehyde 12 via initial N-(4-nitro)phenylation of the indole nucleus, elongation of the 2-aldehyde substituent, and then construction of the pyridine nucleus in order to ensure the nitrogen substitution in 2.

本文言語	English
ページ（範囲）	455-462
ページ数	8
ジャーナル	Heterocycles
巻	80
号	1
DOI	https://doi.org/10.3987/COM-09-S(S)45
出版ステータス	Published - 2010 1月 1

ASJC Scopus subject areas

分析化学
薬理学
有機化学

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10.3987/COM-09-S(S)45

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「Chemical confirmation of the structure of a mutagenic aminophenylnorharman, 9-(4'-aminophenyl)-9H-pyrido[3,4-b]indole: An authentic synthesis of 9-(4'nitrophenyl)-9H- pyrido[3,4-b]indole as its relay compound」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

Murakami, Y., Imai, N., Miura, T., Sugimura, T., Wakabayashi, K., Totsuka, Y., Hada, N., Yokoyama, Y., Suzuki, H., & Mitsunaga, K. (2010). Chemical confirmation of the structure of a mutagenic aminophenylnorharman, 9-(4'-aminophenyl)-9H-pyrido[3,4-b]indole: An authentic synthesis of 9-(4'nitrophenyl)-9H- pyrido[3,4-b]indole as its relay compound. Heterocycles, 80(1), 455-462. https://doi.org/10.3987/COM-09-S(S)45

Murakami, Y, Imai, N, Miura, T, Sugimura, T, Wakabayashi, K, Totsuka, Y, Hada, N, Yokoyama, Y, Suzuki, H & Mitsunaga, K 2010, 'Chemical confirmation of the structure of a mutagenic aminophenylnorharman, 9-(4'-aminophenyl)-9H-pyrido[3,4-b]indole: An authentic synthesis of 9-(4'nitrophenyl)-9H- pyrido[3,4-b]indole as its relay compound', Heterocycles, vol. 80, no. 1, pp. 455-462. https://doi.org/10.3987/COM-09-S(S)45

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abstract = "9-(4'-Aminophenyl)-9H-pyrido[3,4-b]indole 2 is a mutagenic compound produced by non-mutagenic norharman 1 and aniline in the presence of S9 mix. 9-(4'-Nitrophenyl)-9H-pyrido[3,4-b]indole 4, the relay compound for synthesis of 2, was synthesized starting from ethyl indole-2-aldehyde 12 via initial N-(4-nitro)phenylation of the indole nucleus, elongation of the 2-aldehyde substituent, and then construction of the pyridine nucleus in order to ensure the nitrogen substitution in 2.",

keywords = "9H-Pyrido[3,4-b]indole, Cyclization, Indole Nucleus, Norharman, Synthesis",

author = "Yasuoki Murakami and Nobuyuki Imai and Tsuyoshi Miura and Takashi Sugimura and Keiji Wakabayashi and Yukari Totsuka and Noriyasu Hada and Yuusaku Yokoyama and Hideharu Suzuki and Katsuyoshi Mitsunaga",

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doi = "10.3987/COM-09-S(S)45",

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T2 - An authentic synthesis of 9-(4'nitrophenyl)-9H- pyrido[3,4-b]indole as its relay compound

AU - Murakami, Yasuoki

AU - Imai, Nobuyuki

AU - Miura, Tsuyoshi

AU - Sugimura, Takashi

AU - Wakabayashi, Keiji

AU - Totsuka, Yukari

AU - Hada, Noriyasu

AU - Yokoyama, Yuusaku

AU - Suzuki, Hideharu

AU - Mitsunaga, Katsuyoshi

PY - 2010/1/1

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N2 - 9-(4'-Aminophenyl)-9H-pyrido[3,4-b]indole 2 is a mutagenic compound produced by non-mutagenic norharman 1 and aniline in the presence of S9 mix. 9-(4'-Nitrophenyl)-9H-pyrido[3,4-b]indole 4, the relay compound for synthesis of 2, was synthesized starting from ethyl indole-2-aldehyde 12 via initial N-(4-nitro)phenylation of the indole nucleus, elongation of the 2-aldehyde substituent, and then construction of the pyridine nucleus in order to ensure the nitrogen substitution in 2.

AB - 9-(4'-Aminophenyl)-9H-pyrido[3,4-b]indole 2 is a mutagenic compound produced by non-mutagenic norharman 1 and aniline in the presence of S9 mix. 9-(4'-Nitrophenyl)-9H-pyrido[3,4-b]indole 4, the relay compound for synthesis of 2, was synthesized starting from ethyl indole-2-aldehyde 12 via initial N-(4-nitro)phenylation of the indole nucleus, elongation of the 2-aldehyde substituent, and then construction of the pyridine nucleus in order to ensure the nitrogen substitution in 2.

KW - 9H-Pyrido[3,4-b]indole

KW - Cyclization

KW - Indole Nucleus

KW - Norharman

KW - Synthesis

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