TY - JOUR
T1 - Chemical decontamination of iPS cell-derived neural cell mixtures
AU - Mao, Di
AU - Chung, Xie Khim Watson
AU - Andoh-Noda, Tomoko
AU - Qin, Ying
AU - Sato, Shin Ichi
AU - Takemoto, Yasushi
AU - Akamatsu, Wado
AU - Okano, Hideyuki
AU - Uesugi, Motonari
N1 - Funding Information:
This research is supported by the project, ‘‘Development of Cell Production and Processing Systems for Commercialization of Regenerative Medicine,’’ from the Japan Agency for Medical Research and Development, AMED. This work is also supported in part by JSPS (26220206 to M.U.). This work was inspired by JSPS CORE-to-CORE ‘‘Asian Chemical Biology Initiative.’’
Publisher Copyright:
© 2018 The Royal Society of Chemistry.
PY - 2018
Y1 - 2018
N2 - This report describes the design and evaluation of phosphorylated 7-ethyl-10-hydroxycamptothecin (SN38-P), which selectively eliminates tumor-forming proliferative stem cells, including human induced pluripotent stem cells (hiPSCs) and neural stem cells, from iPSC-derived neural cell mixtures. Results of the present study demonstrate that simple phosphorylation of an anticancer drug can provide a safe, cost-effective, and chemically-defined tool for decontaminating hiPSC-derived neuron.
AB - This report describes the design and evaluation of phosphorylated 7-ethyl-10-hydroxycamptothecin (SN38-P), which selectively eliminates tumor-forming proliferative stem cells, including human induced pluripotent stem cells (hiPSCs) and neural stem cells, from iPSC-derived neural cell mixtures. Results of the present study demonstrate that simple phosphorylation of an anticancer drug can provide a safe, cost-effective, and chemically-defined tool for decontaminating hiPSC-derived neuron.
UR - http://www.scopus.com/inward/record.url?scp=85041395901&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041395901&partnerID=8YFLogxK
U2 - 10.1039/c7cc08686e
DO - 10.1039/c7cc08686e
M3 - Article
C2 - 29350722
AN - SCOPUS:85041395901
SN - 1359-7345
VL - 54
SP - 1355
EP - 1358
JO - Chemical Communications
JF - Chemical Communications
IS - 11
ER -