Chemical glycan conjugation controls the biodistribution and kinetics of proteins in live animals

A. Ogura, A. Kurbangalieva, K. Tanaka

研究成果: Article査読

7 被引用数 (Scopus)

抄録

The biodistributions and in vivo kinetics of chemically prepared neoglycoproteins have been examined previously and are reviewed here. A variety of mono- and oligosaccharides may be conjugated onto a protein surface using chemical methods. The kinetics and organ-specific accumulation profiles of these glycoconjugates, introduced through intravenous injection, have been analyzed using conventional dissection studies as well as noninvasive methods, such as SPECT, PET, or fluorescence imaging. These studies have revealed glycan-dependent protein distribution kinetics that may be useful for pharmacological and diagnostic applications.

本文言語English
ページ(範囲)1072-1077
ページ数6
ジャーナルMini-Reviews in Medicinal Chemistry
14
13
DOI
出版ステータスPublished - 2014 10月 1
外部発表はい

ASJC Scopus subject areas

  • 分子医療
  • 薬理学
  • 創薬
  • 癌研究

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