Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptake

Mariko Hara-Chikuma, Shunsuke Chikuma, Yoshinori Sugiyama, Kenji Kabashima, Alan S. Verkman, Shintaro Inoue, Yoshiki Miyachi

研究成果: Article査読

85 被引用数 (Scopus)

抄録

Chemokine-dependent trafficking is indispensable for the effector function of antigenexperienced T cells during immune responses. In this study, we report that the water/glycerol channel aquaporin-3 (AQP3) is expressed on T cells and regulates their trafficking in cutaneous immune reactions. T cell migration toward chemokines is dependent on AQP3-mediated hydrogen peroxide (H2O2) uptake but not the canonical water/glycerol transport. AQP3-mediated H2O2 transport is essential for the activation of the Rho family GTPase Cdc42 and the subsequent actin dynamics. Coincidentally, AQP3-deficient mice are defective in the development of hapten-induced contact hypersensitivity, which is attributed to the impaired trafficking of antigen-primed T cells to the hapten-challenged skin. We therefore suggest that AQP3-mediated H2O2 uptake is required for chemokine-dependent T cell migration in sufficient immune response.

本文言語English
ページ(範囲)1743-1752
ページ数10
ジャーナルJournal of Experimental Medicine
209
10
DOI
出版ステータスPublished - 2012 9

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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