Chemosensitivity testing of clinical gastrointestinal cancers using histoculture and the MTT end-point

T. Furukawa, T. Kubota, M. Watanabe, S. Kase, T. Takahara, H. Yamaguchi, T. Takeuchi, T. Teramoto, K. Ishibiki, M. Kitajima, R. M. Hoffman

研究成果: Article査読

30 被引用数 (Scopus)

抄録

Three-dimensional histoculture with the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazolium bromide (MTT) end-point was utilized for chemosensitivity testing of 100 clinical gastrointestinal cancers and the results were compared with those obtained with cell-suspension culture with the MTT end-point. Of the 100 surgical specimens, 91 were evaluable using histoculture assay and 66 were evaluable using the cell-suspension assay. When the assay results were compared with historical frequency of clinical response to chemotherapy, the results of the histoculture assay showed a closer correlation than those of the cell-suspension assay. Therefore, the histoculture assay seems to have a higher evaluability rate and a closer correlation with clinical chemosensitivity of gastrointestinal cancers than the cell-suspension assay.

本文言語English
ページ(範囲)1377-1382
ページ数6
ジャーナルAnticancer research
12
5
出版ステータスPublished - 1992 1 1

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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