Chiral Bipyridine Ligand with Flexible Molecular Recognition Site: Development and Application to Copper-Catalyzed Asymmetric Borylation of α,β-Unsaturated Ketones

Ryosuke Tsutsumi, Rika Taguchi, Masahiro Yamanaka

研究成果: Article査読

抄録

A novel chiral bipyridine ligand bearing a flexible side chain with a molecular recognition site enables precise stereocontrol through the cooperative action of metal center and hydrogen bonds. This new chiral ligand was applied to the copper-catalyzed asymmetric borylation of α,β-unsaturated carbonyl compounds. The reaction afforded the corresponding borylated products in good yields with high enantioselectivities. Preliminary studies of the functional group-selective transformation revealed that the newly designed chiral bipyridine ligand has the potential to control chemo- and site selectivity in addition to stereoselectivity.

本文言語English
論文番号e202101278
ジャーナルChemCatChem
14
2
DOI
出版ステータスPublished - 2022 1月 21
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 物理化学および理論化学
  • 有機化学
  • 無機化学

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