Chiral copper(II) phosphate catalyzed enantioselective synthesis of isochromene derivatives by sequential intramolecular cyclization and asymmetric transfer hydrogenation of o-alkynylacetophenones

Kodai Saito, Yuki Kajiwara, Takahiko Akiyama

研究成果: Article査読

76 被引用数 (Scopus)

抄録

A good mix: The title reaction of o-alkynylacetophenones with the Hantzsch ester in the presence of a chiral copper/phosphate catalyst proceeds in good yields with excellent enantioselectivities. The key intermediate for enantiocontrol is the ion pair of the carbonyl ylide with a chiral phosphate anion, and this process provides straight forward access to highly enantioriched chiral isochromenes.

本文言語English
ページ(範囲)13284-13288
ページ数5
ジャーナルAngewandte Chemie - International Edition
52
50
DOI
出版ステータスPublished - 2013 12 9
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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