Chiral discrimination of N-carbazole-carbonyl derivatives of α-amino acids with a short linear alkyl side chain by bovine serum albumin

Yoshihiro Abe, Tomoko Shoji, Mamiko Matsubara, Midori Yoshida, Setsuro Sugata, Kazunori Iwata, Hiroshi Suzuki

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Chiral discrimination of racemic carbazole carbonyl (CC)-amino acids with linear alkyl sidechain (C1-C4) by bovine serum albumin (BSA) was investigated by competitive replacement experiments using dansyl-L-proline and dansyl-D-norvaline as fluorescent probes. It was found that the CC derivatives of the D-forms of alanine (C1), amino butyric acid (C2), norvaline (C3), and norleucine (C4) bound to the dansyl-L-proline site much more strongly than their L-forms, whereas the interactions between both enantiomers of these amino acids with dansyl-D-norvaline site were slight. (C) 2000 Wiley-Liss, Inc.

本文言語English
ページ(範囲)565-567
ページ数3
ジャーナルChirality
12
7
DOI
出版ステータスPublished - 2000 1月 1

ASJC Scopus subject areas

  • 分析化学
  • 触媒
  • 薬理学
  • 創薬
  • 分光学
  • 有機化学

フィンガープリント

「Chiral discrimination of N-carbazole-carbonyl derivatives of α-amino acids with a short linear alkyl side chain by bovine serum albumin」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル