Chiral Metal Salts as Ligands for Catalytic Asymmetric Mannich Reactions with Simple Amides

Yasuhiro Yamashita, Aika Noguchi, Seiya Fushimi, Miho Hatanaka, Shū Kobayashi

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Catalytic asymmetric Mannich reactions of imines with weakly acidic simple amides were developed using a chiral potassium hexamethyldisilazide (KHMDS)-bis(oxazoline) potassium salt (K-Box) catalyst system. The desired reactions proceeded to afford the target compounds in high yields with high diastereo- and enantioselectivities. It was suggested that a K enolate interacted with K-Box to form a chiral K enolate that reacted with imines efficiently. In this system, K-Box (potassium salt of Box) worked as a chiral ligand of the active potassium species.

本文言語English
ページ(範囲)5598-5604
ページ数7
ジャーナルJournal of the American Chemical Society
143
15
DOI
出版ステータスPublished - 2021 4 21

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)
  • 生化学
  • コロイド化学および表面化学

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