Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress

Junko Murai, Hongliang Zhang, Lorinc Pongor, Sai Wen Tang, Ukhyun Jo, Fumiya Moribe, Yixiao Ma, Masaru Tomita, Yves Pommier

研究成果: Article査読

抄録

Schlafen 11 (SLFN11), a promising therapeutic biomarker, binds chromatin and sensitizes cancer cells to DNA-targeting agents by blocking DNA replication. Murai et al. show that, in response to replication stress, SLFN11 selectively increases chromatin accessibility at promoters and activates a subset of genes known as the immediate early genes (IEGs).

本文言語English
ページ(範囲)4137-4151.e6
ジャーナルCell Reports
30
12
DOI
出版ステータスPublished - 2020 3 24

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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