Chromosome aberrations induced by high-LET radiations.

Tetsuya Kawata, Hisao Ito, Kerry George, Honglu Wu, Francis A. Cucinotta

研究成果: Article

20 引用 (Scopus)

抄録

Measurements of chromosome aberrations in peripheral blood lymphocytes are currently the most sensitive and reliable indicator of radiation exposure that can be used for biological dosimetry. This technique has been implemented recently to study radiation exposures incurred by astronauts during space flight, where a significant proportion of the dose is delivered by high-LET particle exposure. Traditional methods for the assessing of cytogenetic damage in mitotic cells collected at one time point after exposure may not be suitable for measuring high-LET radiation effects due to the drastic cell cycle perturbations and interphase cell death induced by this type of exposure. In this manuscript we review the recent advances in methodology used to study high-LET induced cytogenetic effects and evaluate the use of chemically-induced Premature Chromosome Condensation (PCC) as an alternative to metaphase analysis. Published data on the cytogenetic effects of in vitro exposures of high-LET radiation is reviewed, along with biodosimetry results from astronauts after short or long space missions.

元の言語English
ページ(範囲)216-223
ページ数8
ジャーナルBiological sciences in space = Uchū seibutsu kagaku
18
発行部数4
出版物ステータスPublished - 2004
外部発表Yes

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Linear Energy Transfer
Chromosome Aberrations
Cytogenetics
Radiation
Astronauts
Space Flight
Interphase
Radiation Effects
Metaphase
Cell Cycle
Cell Death
Chromosomes
Lymphocytes
Radiation Exposure

これを引用

Kawata, T., Ito, H., George, K., Wu, H., & Cucinotta, F. A. (2004). Chromosome aberrations induced by high-LET radiations. Biological sciences in space = Uchū seibutsu kagaku, 18(4), 216-223.

Chromosome aberrations induced by high-LET radiations. / Kawata, Tetsuya; Ito, Hisao; George, Kerry; Wu, Honglu; Cucinotta, Francis A.

:: Biological sciences in space = Uchū seibutsu kagaku, 巻 18, 番号 4, 2004, p. 216-223.

研究成果: Article

Kawata, T, Ito, H, George, K, Wu, H & Cucinotta, FA 2004, 'Chromosome aberrations induced by high-LET radiations.', Biological sciences in space = Uchū seibutsu kagaku, 巻. 18, 番号 4, pp. 216-223.
Kawata, Tetsuya ; Ito, Hisao ; George, Kerry ; Wu, Honglu ; Cucinotta, Francis A. / Chromosome aberrations induced by high-LET radiations. :: Biological sciences in space = Uchū seibutsu kagaku. 2004 ; 巻 18, 番号 4. pp. 216-223.
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