Chronic kidney disease is a risk factor for cardiovascular death in a community-based population in Japan - NIPPON DATA90

Koshi Nakamura, Tomonori Okamura, Takehito Hayakawa, Takashi Kadowaki, Yoshikuni Kita, Hirofumi Ohnishi, Shigeyuki Saitoh, Kiyomi Sakata, Akira Okayama, Hirotsugu Ueshima

研究成果: Article

80 引用 (Scopus)

抄録

Background: Chronic kidney disease (CKD) has been identified as a risk factor for cardiovascular disease (CVD). Methods and Results: The risk of cardiovascular death was evaluated in a large cohort of participants selected randomly from the overall Japanese population. Participants (mean age, 52.4 years) free of previous CVD were followed up for 10 years. Glomerular filtration rate (GFR) was estimated using the abbreviated equation developed at the Cleveland Clinic laboratory for the Modification of Diet in Renal Disease study. Of the 7,316 participants, 6.7% had CKD with a GFR <60 at baseline. Even after adjustment for other risk factors, the presence of CKD conferred an increased risk of cardiovascular death with a hazard ratio of 1.20 (95% confidence interval, 0.82-1.76). Furthermore, a negative, graded correlation between GFR and risk of cardiovascular death was observed: 1.09 (0.72-1.64) for a 60≤ GFR <90, 1.15 (0.67-1.99) for a 45≤ GFR <60, 1.23 (0.49-3.09) for a 30≤ GFR <45, 5.52 (1.62-18.75) for a 15≤ GFR <30, 9.12 (2.12-39.29) for a GFR <15, as compared with normal kidney function (GFR ≥90). The proportion of excess cardiovascular death due to CKD was 1.3%. Conclusion: CKD was an independent risk factor for cardiovascular death in a community-dwelling Japanese population.

元の言語English
ページ(範囲)954-959
ページ数6
ジャーナルCirculation Journal
70
発行部数8
DOI
出版物ステータスPublished - 2006
外部発表Yes

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Glomerular Filtration Rate
Chronic Renal Insufficiency
Japan
Population
Cardiovascular Diseases
Independent Living
Diet Therapy
Kidney
Confidence Intervals

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

これを引用

Chronic kidney disease is a risk factor for cardiovascular death in a community-based population in Japan - NIPPON DATA90. / Nakamura, Koshi; Okamura, Tomonori; Hayakawa, Takehito; Kadowaki, Takashi; Kita, Yoshikuni; Ohnishi, Hirofumi; Saitoh, Shigeyuki; Sakata, Kiyomi; Okayama, Akira; Ueshima, Hirotsugu.

:: Circulation Journal, 巻 70, 番号 8, 2006, p. 954-959.

研究成果: Article

Nakamura, K, Okamura, T, Hayakawa, T, Kadowaki, T, Kita, Y, Ohnishi, H, Saitoh, S, Sakata, K, Okayama, A & Ueshima, H 2006, 'Chronic kidney disease is a risk factor for cardiovascular death in a community-based population in Japan - NIPPON DATA90', Circulation Journal, 巻. 70, 番号 8, pp. 954-959. https://doi.org/10.1253/circj.70.954
Nakamura, Koshi ; Okamura, Tomonori ; Hayakawa, Takehito ; Kadowaki, Takashi ; Kita, Yoshikuni ; Ohnishi, Hirofumi ; Saitoh, Shigeyuki ; Sakata, Kiyomi ; Okayama, Akira ; Ueshima, Hirotsugu. / Chronic kidney disease is a risk factor for cardiovascular death in a community-based population in Japan - NIPPON DATA90. :: Circulation Journal. 2006 ; 巻 70, 番号 8. pp. 954-959.
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abstract = "Background: Chronic kidney disease (CKD) has been identified as a risk factor for cardiovascular disease (CVD). Methods and Results: The risk of cardiovascular death was evaluated in a large cohort of participants selected randomly from the overall Japanese population. Participants (mean age, 52.4 years) free of previous CVD were followed up for 10 years. Glomerular filtration rate (GFR) was estimated using the abbreviated equation developed at the Cleveland Clinic laboratory for the Modification of Diet in Renal Disease study. Of the 7,316 participants, 6.7{\%} had CKD with a GFR <60 at baseline. Even after adjustment for other risk factors, the presence of CKD conferred an increased risk of cardiovascular death with a hazard ratio of 1.20 (95{\%} confidence interval, 0.82-1.76). Furthermore, a negative, graded correlation between GFR and risk of cardiovascular death was observed: 1.09 (0.72-1.64) for a 60≤ GFR <90, 1.15 (0.67-1.99) for a 45≤ GFR <60, 1.23 (0.49-3.09) for a 30≤ GFR <45, 5.52 (1.62-18.75) for a 15≤ GFR <30, 9.12 (2.12-39.29) for a GFR <15, as compared with normal kidney function (GFR ≥90). The proportion of excess cardiovascular death due to CKD was 1.3{\%}. Conclusion: CKD was an independent risk factor for cardiovascular death in a community-dwelling Japanese population.",
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T1 - Chronic kidney disease is a risk factor for cardiovascular death in a community-based population in Japan - NIPPON DATA90

AU - Nakamura, Koshi

AU - Okamura, Tomonori

AU - Hayakawa, Takehito

AU - Kadowaki, Takashi

AU - Kita, Yoshikuni

AU - Ohnishi, Hirofumi

AU - Saitoh, Shigeyuki

AU - Sakata, Kiyomi

AU - Okayama, Akira

AU - Ueshima, Hirotsugu

PY - 2006

Y1 - 2006

N2 - Background: Chronic kidney disease (CKD) has been identified as a risk factor for cardiovascular disease (CVD). Methods and Results: The risk of cardiovascular death was evaluated in a large cohort of participants selected randomly from the overall Japanese population. Participants (mean age, 52.4 years) free of previous CVD were followed up for 10 years. Glomerular filtration rate (GFR) was estimated using the abbreviated equation developed at the Cleveland Clinic laboratory for the Modification of Diet in Renal Disease study. Of the 7,316 participants, 6.7% had CKD with a GFR <60 at baseline. Even after adjustment for other risk factors, the presence of CKD conferred an increased risk of cardiovascular death with a hazard ratio of 1.20 (95% confidence interval, 0.82-1.76). Furthermore, a negative, graded correlation between GFR and risk of cardiovascular death was observed: 1.09 (0.72-1.64) for a 60≤ GFR <90, 1.15 (0.67-1.99) for a 45≤ GFR <60, 1.23 (0.49-3.09) for a 30≤ GFR <45, 5.52 (1.62-18.75) for a 15≤ GFR <30, 9.12 (2.12-39.29) for a GFR <15, as compared with normal kidney function (GFR ≥90). The proportion of excess cardiovascular death due to CKD was 1.3%. Conclusion: CKD was an independent risk factor for cardiovascular death in a community-dwelling Japanese population.

AB - Background: Chronic kidney disease (CKD) has been identified as a risk factor for cardiovascular disease (CVD). Methods and Results: The risk of cardiovascular death was evaluated in a large cohort of participants selected randomly from the overall Japanese population. Participants (mean age, 52.4 years) free of previous CVD were followed up for 10 years. Glomerular filtration rate (GFR) was estimated using the abbreviated equation developed at the Cleveland Clinic laboratory for the Modification of Diet in Renal Disease study. Of the 7,316 participants, 6.7% had CKD with a GFR <60 at baseline. Even after adjustment for other risk factors, the presence of CKD conferred an increased risk of cardiovascular death with a hazard ratio of 1.20 (95% confidence interval, 0.82-1.76). Furthermore, a negative, graded correlation between GFR and risk of cardiovascular death was observed: 1.09 (0.72-1.64) for a 60≤ GFR <90, 1.15 (0.67-1.99) for a 45≤ GFR <60, 1.23 (0.49-3.09) for a 30≤ GFR <45, 5.52 (1.62-18.75) for a 15≤ GFR <30, 9.12 (2.12-39.29) for a GFR <15, as compared with normal kidney function (GFR ≥90). The proportion of excess cardiovascular death due to CKD was 1.3%. Conclusion: CKD was an independent risk factor for cardiovascular death in a community-dwelling Japanese population.

KW - Cardiovascular disease

KW - Chronic kidney disease

KW - Glomerular filtration rate

KW - Mortality

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