Cicatricial pemphigoid of the oropharynx after allogeneic stem cell transplantation for relapsed follicular lymphoma

Yoshinobu Aisa, Takehiko Mori, Tomonori Nakazato, Rie Yamazaki, Jun Yamagami, Masayuki Amagai, Yasuo Ikeda, Shinichiro Okamoto

研究成果: Article査読

7 被引用数 (Scopus)

抄録

A 44-year-old woman with refractory follicular lymphoma underwent allogeneic stem cell transplantation (SCT) and achieved complete remission. Grade III acute graft-versus-host disease (GVHD) developed on day 23, but no chronic GVHD occurred. The patient developed severe erosion with bullous lesions in the oral cavity 18 months after SCT. At that time, the lymphoma remained in complete remission, and she had no clinical or laboratory findings suggesting chronic GVHD. A biopsy of the oral mucosa showed moderate lymphoplasmacytic infiltration and subepidermal bullae, and direct immunofluorescence staining demonstrated linear deposition of C3 at the dermo-epidermal junction. An immunoblotting assay using human epidermal extracts confirmed the presence in her serum of an antibody against the 230-kd bullous pemphigoid antigen 1 (BPAG1). A diagnosis of cicatricial pemphigoid (CP) was made, and complete resolution of the CP was achieved with prednisolone therapy. The occurrence of autoimmune blistering diseases is rare after allogeneic SCT.

本文言語English
ページ(範囲)266-269
ページ数4
ジャーナルInternational journal of hematology
82
3
DOI
出版ステータスPublished - 2005 10

ASJC Scopus subject areas

  • Hematology

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