Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration

Marisol Cano, Rajesh Thimmalappula, Masashi Fujihara, Norihiro Nagai, Michael Sporn, Ai Ling Wang, Arthur H. Neufeld, Shyam Biswal, James T. Handa

研究成果: Article査読

147 被引用数 (Scopus)

抄録

Age-related Macular Degeneration (AMD) is the leading cause of blindness among the elderly. While excellent treatment has emerged for neovascular disease, treatment for early AMD is lacking due to an incomplete understanding of the early molecular events. Cigarette smoking is the strongest epidemiologic risk factor, yet we do not understand how smoking contributes to AMD. Smoking related oxidative damage during the early phases of AMD may play an important role. This review explores how cigarette smoking and oxidative stress to the retinal pigmented epithelium (RPE) might contribute to AMD, and how the transcription factor Nrf2 can activate a cytoprotective response.

本文言語English
ページ(範囲)652-664
ページ数13
ジャーナルVision Research
50
7
DOI
出版ステータスPublished - 2010 3
外部発表はい

ASJC Scopus subject areas

  • 眼科学
  • 感覚系

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