Circulating levels of MMP-1, -2, -3, -9, and TIMP-1 are increased in POEMS syndrome

K. Michizono, F. Umehara, T. Hashiguchi, K. Arimura, E. Matsuura, O. Watanabe, N. Fujimoto, Y. Okada, M. Osame

研究成果: Article査読

25 被引用数 (Scopus)

抄録

The authors quantitatively measured levels of matrix metalloproteinases (MMP), tissue inhibitor of metalloproteinases (TIMP), and vascular endothelial growth factor (VEGF) in blood samples of POEMS syndrome. Circulating levels of MMP-1, -2, -3, -9, and TIMP-1 were more increased in patients with POEMS syndrome than in patients with other neurologic disorders or in healthy controls. Serum levels of VEGF and TIMP-1 were strongly correlated with each other. Increased circulating levels of MMP-1, -2, -3, -9, and TIMP-1 may lead to a better understanding the pathogenesis of POEMS syndrome.

本文言語English
ページ(範囲)807-810
ページ数4
ジャーナルNeurology
56
6
DOI
出版ステータスPublished - 2001 3 27

ASJC Scopus subject areas

  • 臨床神経学

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