Circulating microRNAs and extracellular vesicles as potential cancer biomarkers: a systematic review

Juntaro Matsuzaki, Takahiro Ochiya

研究成果: Review article査読

53 被引用数 (Scopus)

抄録

Circulating non-coding RNAs, including microRNAs and long non-coding RNAs, and the protein components of extracellular vesicles are promising biomarkers for the non-invasive detection of cancer at an early stage. This systematic review discusses the increasing number of well-designed cancer biomarker-related studies that have been published worldwide. In many of these studies, high diagnostic accuracy, which is represented as the area under the receiver operating characteristic curve being >0.8, could be achieved using combinations of circulating microRNAs. In addition, similar diagnostic accuracies were reported using long non-coding RNAs or proteins present in extracellular vesicles, although these evidences were based on a limited number of studies.

本文言語English
ページ(範囲)413-420
ページ数8
ジャーナルInternational Journal of Clinical Oncology
22
3
DOI
出版ステータスPublished - 2017 6 1

ASJC Scopus subject areas

  • 外科
  • 血液学
  • 腫瘍学

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