Clear cell endocrine tumor of the pancreas which is not associated with von Hippel-Lindau disease: Report of a case

Souya Nunobe, Noriyoshi Fukushima, Shinichi Yachida, Kazuaki Shimada, Tomoo Kosuge, Michiie Sakamoto

研究成果: Article

17 引用 (Scopus)

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We describe the case of a pancreatic endocrine tumor with marked clear cell changes. The patient, a 56-year-old woman, presented with appetite loss and nausea but no evidence of either von Hippel-Lindau disease, or a family history of the disease. A radiological examination revealed a hypervascular tumor measuring 5.2cm in diameter located in the pancreatic head. The patient underwent a pylorus-preserving pancreatoduodenectomy. The cut surface of the tumor was yellowish and well demarcated. Histologically, the tumor was composed of cuboidal cells with clear cytoplasm, thus forming trabecular and insular nests. Immunohistochemically, the tumor cells were strongly positive for chromogranin. An electron microscopic examination revealed the tumor cells to contain neuroendocrine secretory granules, abundant lipid droplets, and some crystalloid bodies in the cytoplasm. We conclusively diagnosed it to be a pancreatic clear cell endocrine umor. Such tumors not associated with von Hippel-Lindau disease are extremely rare.

元の言語English
ページ(範囲)470-474
ページ数5
ジャーナルSurgery today
33
発行部数6
DOI
出版物ステータスPublished - 2003 6 12
外部発表Yes

ASJC Scopus subject areas

  • Surgery

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