抄録
We describe the case of a pancreatic endocrine tumor with marked clear cell changes. The patient, a 56-year-old woman, presented with appetite loss and nausea but no evidence of either von Hippel-Lindau disease, or a family history of the disease. A radiological examination revealed a hypervascular tumor measuring 5.2cm in diameter located in the pancreatic head. The patient underwent a pylorus-preserving pancreatoduodenectomy. The cut surface of the tumor was yellowish and well demarcated. Histologically, the tumor was composed of cuboidal cells with clear cytoplasm, thus forming trabecular and insular nests. Immunohistochemically, the tumor cells were strongly positive for chromogranin. An electron microscopic examination revealed the tumor cells to contain neuroendocrine secretory granules, abundant lipid droplets, and some crystalloid bodies in the cytoplasm. We conclusively diagnosed it to be a pancreatic clear cell endocrine umor. Such tumors not associated with von Hippel-Lindau disease are extremely rare.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 470-474 |
| ページ数 | 5 |
| ジャーナル | Surgery Today |
| 巻 | 33 |
| 発行部数 | 6 |
| DOI | |
| 出版物ステータス | Published - 2003 |
| 外部発表 | Yes |
Fingerprint
ASJC Scopus subject areas
- Surgery
これを引用
Clear cell endocrine tumor of the pancreas which is not associated with von Hippel-Lindau disease : Report of a case. / Nunobe, Souya; Fukushima, Noriyoshi; Yachida, Shinichi; Shimada, Kazuaki; Kosuge, Tomoo; Sakamoto, Michiie.
：: Surgery Today, 巻 33, 番号 6, 2003, p. 470-474.研究成果: Article
}
TY - JOUR
T1 - Clear cell endocrine tumor of the pancreas which is not associated with von Hippel-Lindau disease
T2 - Report of a case
AU - Nunobe, Souya
AU - Fukushima, Noriyoshi
AU - Yachida, Shinichi
AU - Shimada, Kazuaki
AU - Kosuge, Tomoo
AU - Sakamoto, Michiie
PY - 2003
Y1 - 2003
N2 - We describe the case of a pancreatic endocrine tumor with marked clear cell changes. The patient, a 56-year-old woman, presented with appetite loss and nausea but no evidence of either von Hippel-Lindau disease, or a family history of the disease. A radiological examination revealed a hypervascular tumor measuring 5.2cm in diameter located in the pancreatic head. The patient underwent a pylorus-preserving pancreatoduodenectomy. The cut surface of the tumor was yellowish and well demarcated. Histologically, the tumor was composed of cuboidal cells with clear cytoplasm, thus forming trabecular and insular nests. Immunohistochemically, the tumor cells were strongly positive for chromogranin. An electron microscopic examination revealed the tumor cells to contain neuroendocrine secretory granules, abundant lipid droplets, and some crystalloid bodies in the cytoplasm. We conclusively diagnosed it to be a pancreatic clear cell endocrine umor. Such tumors not associated with von Hippel-Lindau disease are extremely rare.
AB - We describe the case of a pancreatic endocrine tumor with marked clear cell changes. The patient, a 56-year-old woman, presented with appetite loss and nausea but no evidence of either von Hippel-Lindau disease, or a family history of the disease. A radiological examination revealed a hypervascular tumor measuring 5.2cm in diameter located in the pancreatic head. The patient underwent a pylorus-preserving pancreatoduodenectomy. The cut surface of the tumor was yellowish and well demarcated. Histologically, the tumor was composed of cuboidal cells with clear cytoplasm, thus forming trabecular and insular nests. Immunohistochemically, the tumor cells were strongly positive for chromogranin. An electron microscopic examination revealed the tumor cells to contain neuroendocrine secretory granules, abundant lipid droplets, and some crystalloid bodies in the cytoplasm. We conclusively diagnosed it to be a pancreatic clear cell endocrine umor. Such tumors not associated with von Hippel-Lindau disease are extremely rare.
KW - Clear cell
KW - Endocrine tumor
KW - Immunohistochemistry
KW - Ultrastructural examination
UR - http://www.scopus.com/inward/record.url?scp=0037683364&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037683364&partnerID=8YFLogxK
U2 - 10.1007/s10595-002-2508-x
DO - 10.1007/s10595-002-2508-x
M3 - Article
C2 - 12768377
AN - SCOPUS:0037683364
VL - 33
SP - 470
EP - 474
JO - Surgery Today
JF - Surgery Today
SN - 0941-1291
IS - 6
ER -