Clear cell papillary renal cell carcinoma: A review

Naoto Kuroda, Chisato Ohe, Fumi Kawakami, Shuji Mikami, Mitsuko Furuya, Keiko Matsuura, Masatsugu Moriyama, Yoji Nagashima, Ming Zhou, Fredrik Petersson, José I. López, Ondrej Hes, Michal Michal, Mahul B. Amin

研究成果: Review article査読

27 被引用数 (Scopus)

抄録

The disease concept of clear cell (tubulo) papillary renal cell carcinoma (CCP-RCC) as a distinct subtype of renal cell carcinoma has been recently established. First described in the setting of end stage renal disease, this tumor type is more frequently recognized and encountered in a sporadic setting. In this article, we provide an overview of the recent understanding of this tumor. Macroscopically, tumors are well circumscribed with well-developed tumor capsule. Histologically, the tumor cells are cuboidal to low columnar cell with clear cytoplasm and papillary and tubulo-papillary configuration. Immunohistochemically, tumor cells generally show diffuse expression for cytokeratin 7, CA9 (cup-shaped pattern), HIF-1, GLUT-1 and high molecular weight cytokeratin, but negative for AMACR, RCC Ma and TFE3. CD10 is negative or focally positive in most tumors. Genetically, this tumor has no characteristics of clear cell RCC or papillary RCC. Prognostically, patients with CCP-RCC behave in an indolent fashion in all previously reported cases. In conclusion, although this tumor has been integrated into recent International Society of Urologic Pathology Classification of renal neoplasia, both aspects of disease concept and clinical behavior are yet to be fully elucidated. Further publications of large cohorts of patients will truly help understand the biologic potential and the molecular underpinnings of this tumor type.

本文言語English
ページ(範囲)7312-7318
ページ数7
ジャーナルInternational Journal of Clinical and Experimental Pathology
7
11
出版ステータスPublished - 2014
外部発表はい

ASJC Scopus subject areas

  • 病理学および法医学
  • 組織学

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