Clear cell variant of malignant melanoma of the uterine cervix: A case report and review of the literature

Mitsuko Furuya, Michio Shimizu, Hiroshi Nishihara, Tomoo Ito, Noriaki Sakuragi, Hiroshi Ishikura, Takashi Yoshiki

研究成果: Article査読

21 被引用数 (Scopus)

抄録

Background. A rare variant of malignant melanoma of the uterine cervix mimicking clear cell carcinoma or clear cell sarcoma is described. Case. A 33-year-old Japanese woman was admitted to the hospital complaining of genital discharge and lower back pain. The stage was FIGO IIB and radical hysterectomy and pelvic lymphadenectomy were done. Pathological examination, immunohistochemical studies of melanin granules, and molecular analysis of the EWS/ATF-1 fusion gene were also done. A diffuse proliferation of amelanotic clear cells was detected in the uterine cervix. Tumor cells were positive for HMB 45, Melan-A (MART-1), and S-100 protein and negative for epithelial markers. The EWS/ATF-1 fusion gene was not detected. Conclusion. This is apparently the first report of a case of clear cell melanoma of the uterine cervix. Despite its rarity, this variant of malignant melanoma should be considered when diagnosing clear cell neoplasms of the uterine cervix.

本文言語English
ページ(範囲)409-412
ページ数4
ジャーナルGynecologic Oncology
80
3
DOI
出版ステータスPublished - 2001
外部発表はい

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

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