Cleavage of the C-N bond of a peptide group by a copper(II)-peroxide adduct with an η1-coordination mode

Satoshi Nishino; Mami Kunita; Yoshiyuki Kani; Shigeru Ohba; Hideaki Matsushima; Tadashi Tokii; Yuzo Nishida

doi:10.1016/S1387-7003(00)00023-X

Cleavage of the C-N bond of a peptide group by a copper(II)-peroxide adduct with an η¹-coordination mode

Satoshi Nishino, Mami Kunita, Yoshiyuki Kani, Shigeru Ohba, Hideaki Matsushima, Tadashi Tokii, Yuzo Nishida

人文社会学科

研究成果: Article › 査読

20 被引用数 (Scopus)

抄録

We have obtained clear evidence that a copper(II)-peroxide adduct with an η¹-coordination mode can cleave the C-N bond of a peptide group and hydroxylate the alkyl group nearby; this may provide helpful information for elucidation of the reaction mechanism of PAM, peptidylglycine α-amidating monooxygenase. (C) 2000 Elsevier Science S.A.

本文言語	English
ページ（範囲）	145-148
ページ数	4
ジャーナル	Inorganic Chemistry Communications
巻	3
号	3
DOI	https://doi.org/10.1016/S1387-7003(00)00023-X
出版ステータス	Published - 2000 10月 7

ASJC Scopus subject areas

物理化学および理論化学
無機化学
材料化学

文献へのアクセス

10.1016/S1387-7003(00)00023-X

他のファイルとリンク

引用スタイル

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T1 - Cleavage of the C-N bond of a peptide group by a copper(II)-peroxide adduct with an η1-coordination mode

AU - Nishino, Satoshi

AU - Kunita, Mami

AU - Kani, Yoshiyuki

AU - Ohba, Shigeru

AU - Matsushima, Hideaki

AU - Tokii, Tadashi

AU - Nishida, Yuzo

PY - 2000/10/7

Y1 - 2000/10/7

N2 - We have obtained clear evidence that a copper(II)-peroxide adduct with an η1-coordination mode can cleave the C-N bond of a peptide group and hydroxylate the alkyl group nearby; this may provide helpful information for elucidation of the reaction mechanism of PAM, peptidylglycine α-amidating monooxygenase. (C) 2000 Elsevier Science S.A.

AB - We have obtained clear evidence that a copper(II)-peroxide adduct with an η1-coordination mode can cleave the C-N bond of a peptide group and hydroxylate the alkyl group nearby; this may provide helpful information for elucidation of the reaction mechanism of PAM, peptidylglycine α-amidating monooxygenase. (C) 2000 Elsevier Science S.A.

KW - Cleavage of protein

KW - Copper(II)-peroxide adduct

KW - Model reaction for PAM enzyme

KW - η-Coordination mode

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