Click reaction based on the biosynthesis of firefly luciferin

Tomohisa Toyama, Tsuyoshi Saitoh, Yuka Takahashi, Kotaro Oka, Daniel Citterio, Koji Suzuki, Shigeru Nishiyama

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Novel click chemistry was developed based on the biosynthetic process of firefly luciferin, which includes an ideal coupling of a cyanothiazole residue with cysteine. Among various biomimetic couplings of nitriles with cysteine derivatives, the approach using 4-cyanopyridine and cysteine methyl ester provided a very rapid and quantitative conversion to the corresponding thiazole without any metal catalyst at room temperature.

本文言語English
ページ(範囲)753-755
ページ数3
ジャーナルChemistry Letters
46
5
DOI
出版ステータスPublished - 2017

ASJC Scopus subject areas

  • 化学 (全般)

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