Clinical and histological findings associated with autoantibodies detected by RNA immunoprecipitation in inflammatory myopathies

Shigeaki Suzuki, Takahiro Yonekawa, Masataka Kuwana, Yukiko K. Hayashi, Yuka Okazaki, Yasushi Kawaguchi, Norihiro Suzuki, Ichizo Nishino

研究成果: Article査読

46 被引用数 (Scopus)

抄録

Of 207 adult patients with idiopathic inflammatory myopathies, detection of autoantibodies by RNA immunoprecipitation showed that 99 patients (48%) were antibody-positive. We divided these 99 into five subgroups: anti-signal recognition particle (SRP), anti-aminoacyl transfer RNA synthetase, anti-Ku, anti-U1RNP, and anti-SSA/B. Younger age at onset, severe weakness, muscle atrophy, elevated creatine kinase, and necrosis in muscle fibers without inflammatory cell infiltration were found significantly more frequently among the patients with anti-SRP antibodies (n = 41) compared to the antibody-negative patients (n = 108). Autoantibody detection by RNA immunoprecipitation can provide useful information associated with clinical and histological findings.

本文言語English
ページ(範囲)202-208
ページ数7
ジャーナルJournal of Neuroimmunology
274
1-2
DOI
出版ステータスPublished - 2014

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学
  • 神経学
  • 臨床神経学

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