Clinical and immunological differences between early and late-onset myasthenia gravis in Japan

Shigeaki Suzuki, Kimiaki Utsugisawa, Yuriko Nagane, Takashi Satoh, Masataka Kuwana, Norihiro Suzuki

研究成果: Article査読

48 被引用数 (Scopus)

抄録

Immunological characteristics of myasthenia gravis (MG) with late-onset have not been fully elucidated. We examined several autoantibodies and HLA-DRB1 genotyping in 260 Japanese MG patients. Sixty-two MG patients had thymoma. The others were divided into early-onset and late-onset groups separated by an age of 50. years. The ocular form was more frequent in late-onset compared to early-onset group. Seropositivity of anti-muscle-specific tyrosine kinase antibody was 2-3% in acetylcholine receptor-seronegative patients. HLA-DRB1 genotyping failed to detect statistical differences in specific alleles between each group and healthy controls. The immunological profiles in late-onset MG were different from early-onset in Japan.

本文言語English
ページ(範囲)148-152
ページ数5
ジャーナルJournal of Neuroimmunology
230
1-2
DOI
出版ステータスPublished - 2011 1月 1

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学
  • 神経学
  • 臨床神経学

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