Clinical characteristics of Japanese patients with anti-PL-7 (anti-threonyl-tRNA synthetase) autoantibodies

Shinji Sato, Michito Hirakata, Masataka Kuwana, Kunio Nakamura, Akira Suwa, Shinichi Inada, Tsuneyo Mimori, Yasuo Ikeda

研究成果: Article

47 引用 (Scopus)

抄録

Objective: The clinical and laboratory features of seven Japanese patients with anti-aminoacyl-tRNA synthetase (ARS) autoantibodies against PL-7 (anti-threonyl-tRNA synthetase) were analyzed and compared with previously published findings. Methods: Serum samples from 1,135 Japanese patients with various autoimmune diseases were screened for anti-PL-7 antibodies using RNA and protein immunoprecipitation assays. The patients whose sera contained anti-PL-7 antibodies were assessed regarding clinical symptoms and clinical course. Results: Sera from seven patients were found to have anti-PL-7 antibodies. These autoantibodies were associated with polymyositis/dermatomyositis (PM/DM) and/or interstitial lung disease (ILD). The clinical diagnoses of these seven patients were PM - systemic sclerosis (SSc) overlap (5 patients), DM (1 patient) and idiopathic pulmonary fibrosis (IPF) (1 patient). All patients had ILD with a chronic course and six also had arthritis (85%) and five sclerodactyly (71%). Conclusions: These results indicate that anti-PL-7 autoantibodies are closely associated with PM-SSc overlap as well as ILD, arthritis and sclerodactyly in our series of Japanese patients.

元の言語English
ページ(範囲)609-615
ページ数7
ジャーナルClinical and Experimental Rheumatology
23
発行部数5
出版物ステータスPublished - 2005 9

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Threonine-tRNA Ligase
Autoantibodies
Interstitial Lung Diseases
Systemic Scleroderma
Arthritis
Antibodies
Serum
Amino Acyl-tRNA Synthetases
Idiopathic Pulmonary Fibrosis
Dermatomyositis
Immunoprecipitation
Autoimmune Diseases

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

これを引用

Clinical characteristics of Japanese patients with anti-PL-7 (anti-threonyl-tRNA synthetase) autoantibodies. / Sato, Shinji; Hirakata, Michito; Kuwana, Masataka; Nakamura, Kunio; Suwa, Akira; Inada, Shinichi; Mimori, Tsuneyo; Ikeda, Yasuo.

:: Clinical and Experimental Rheumatology, 巻 23, 番号 5, 09.2005, p. 609-615.

研究成果: Article

Sato, S, Hirakata, M, Kuwana, M, Nakamura, K, Suwa, A, Inada, S, Mimori, T & Ikeda, Y 2005, 'Clinical characteristics of Japanese patients with anti-PL-7 (anti-threonyl-tRNA synthetase) autoantibodies', Clinical and Experimental Rheumatology, 巻. 23, 番号 5, pp. 609-615.
Sato, Shinji ; Hirakata, Michito ; Kuwana, Masataka ; Nakamura, Kunio ; Suwa, Akira ; Inada, Shinichi ; Mimori, Tsuneyo ; Ikeda, Yasuo. / Clinical characteristics of Japanese patients with anti-PL-7 (anti-threonyl-tRNA synthetase) autoantibodies. :: Clinical and Experimental Rheumatology. 2005 ; 巻 23, 番号 5. pp. 609-615.
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T1 - Clinical characteristics of Japanese patients with anti-PL-7 (anti-threonyl-tRNA synthetase) autoantibodies

AU - Sato, Shinji

AU - Hirakata, Michito

AU - Kuwana, Masataka

AU - Nakamura, Kunio

AU - Suwa, Akira

AU - Inada, Shinichi

AU - Mimori, Tsuneyo

AU - Ikeda, Yasuo

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N2 - Objective: The clinical and laboratory features of seven Japanese patients with anti-aminoacyl-tRNA synthetase (ARS) autoantibodies against PL-7 (anti-threonyl-tRNA synthetase) were analyzed and compared with previously published findings. Methods: Serum samples from 1,135 Japanese patients with various autoimmune diseases were screened for anti-PL-7 antibodies using RNA and protein immunoprecipitation assays. The patients whose sera contained anti-PL-7 antibodies were assessed regarding clinical symptoms and clinical course. Results: Sera from seven patients were found to have anti-PL-7 antibodies. These autoantibodies were associated with polymyositis/dermatomyositis (PM/DM) and/or interstitial lung disease (ILD). The clinical diagnoses of these seven patients were PM - systemic sclerosis (SSc) overlap (5 patients), DM (1 patient) and idiopathic pulmonary fibrosis (IPF) (1 patient). All patients had ILD with a chronic course and six also had arthritis (85%) and five sclerodactyly (71%). Conclusions: These results indicate that anti-PL-7 autoantibodies are closely associated with PM-SSc overlap as well as ILD, arthritis and sclerodactyly in our series of Japanese patients.

AB - Objective: The clinical and laboratory features of seven Japanese patients with anti-aminoacyl-tRNA synthetase (ARS) autoantibodies against PL-7 (anti-threonyl-tRNA synthetase) were analyzed and compared with previously published findings. Methods: Serum samples from 1,135 Japanese patients with various autoimmune diseases were screened for anti-PL-7 antibodies using RNA and protein immunoprecipitation assays. The patients whose sera contained anti-PL-7 antibodies were assessed regarding clinical symptoms and clinical course. Results: Sera from seven patients were found to have anti-PL-7 antibodies. These autoantibodies were associated with polymyositis/dermatomyositis (PM/DM) and/or interstitial lung disease (ILD). The clinical diagnoses of these seven patients were PM - systemic sclerosis (SSc) overlap (5 patients), DM (1 patient) and idiopathic pulmonary fibrosis (IPF) (1 patient). All patients had ILD with a chronic course and six also had arthritis (85%) and five sclerodactyly (71%). Conclusions: These results indicate that anti-PL-7 autoantibodies are closely associated with PM-SSc overlap as well as ILD, arthritis and sclerodactyly in our series of Japanese patients.

KW - Anti-aminoacyl-tRNA synthetases (ARS) antibodies

KW - Interstitial lung disease (ILD)

KW - Polymyositis/dermatomyositis (PM/DM)

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