Clinical Factors for Rapid Endothelial Cell Loss After Corneal Transplantation: Novel Findings From the Aqueous Humor

Hiroyuki Yazu, Takefumi Yamaguchi, Kazuo Tsubota, Jun Shimazaki

研究成果: Review article査読

1 被引用数 (Scopus)

抄録

Purpose of Review: To review the clinical factors for endothelial cell density (ECD) loss and graft failure after corneal transplantation. Recent Findings: Reduction of ECD after corneal transplantation is associated with various clinical factors, such as the presence of glaucoma, graft diameter, donor age, donor diabetes, and donor gender. Recently, we reported the severe preexisting iris damage was one of the clinical factors for rapid ECD loss and graft failure. We also showed that preexisting iris damage causes chronic elevation of cytokine levels in the aqueous humor (AqH). Furthermore, the higher preoperative levels of specific cytokines in the AqH were associated with a rapid reduction in ECD after penetrating keratoplasty and endothelial keratoplasty. Summary: Iris damage and preoperative cytokine levels in the AqH can be potential biomarkers for the reduction of ECD after corneal transplantation, although we need to substantiate the exact mechanism of the endothelial cell loss.

本文言語English
ページ(範囲)89-97
ページ数9
ジャーナルCurrent Ophthalmology Reports
7
2
DOI
出版ステータスPublished - 2019 6 15

ASJC Scopus subject areas

  • 眼科学

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